TY  - GEN
AU  - Liu,Jian-Ning
AU  - Liu,Jian-Xia
AU  - Liu Bf,Bei-fang
AU  - Sun,Ziyong
AU  - Zuo,Jian-Ling
AU  - Zhang Px,Pei-xiang
AU  - Zhang,Jing
AU  - Chen Yh,Yu-hong
AU  - Gurewich,Victor
TI  - Prourokinase mutant that induces highly effective clot lysis without interfering with hemostasis
SN  - 1524-4571
PY  - 2002///0426
KW  - Amino Acid Substitution
KW  - Animals
KW  - Bleeding Time
KW  - Blood Coagulation
KW  - drug effects
KW  - Disease Models, Animal
KW  - Dogs
KW  - Drug Evaluation, Preclinical
KW  - Drug Stability
KW  - Enzyme Activation
KW  - Femoral Vein
KW  - Fibrin
KW  - Fibrinolysis
KW  - Hemorrhage
KW  - prevention & control
KW  - Hemostasis
KW  - Humans
KW  - Macaca mulatta
KW  - Male
KW  - Mutagenesis, Site-Directed
KW  - Plasma
KW  - Plasminogen
KW  - Recombinant Proteins
KW  - genetics
KW  - Thrombolytic Therapy
KW  - methods
KW  - Thrombosis
KW  - drug therapy
KW  - Tissue Plasminogen Activator
KW  - pharmacology
KW  - Urokinase-Type Plasminogen Activator
N1  - Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1161/01.res.0000014825.71092.bd
ER  -