TY  - GEN
AU  - Maring,J G
AU  - van Kuilenburg,A B P
AU  - Haasjes,J
AU  - Piersma,H
AU  - Groen,H J M
AU  - Uges,D R A
AU  - Van Gennip,A H
AU  - De Vries,E G E
TI  - Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene
SN  - 0007-0920
PY  - 2002///0430
KW  - Aged
KW  - Alleles
KW  - Antimetabolites, Antineoplastic
KW  - adverse effects
KW  - Chromatography, High Pressure Liquid
KW  - Colorectal Neoplasms
KW  - drug therapy
KW  - DNA, Neoplasm
KW  - genetics
KW  - Dihydrouracil Dehydrogenase (NADP)
KW  - Female
KW  - Fluorouracil
KW  - Humans
KW  - Leucovorin
KW  - administration & dosage
KW  - Male
KW  - Middle Aged
KW  - Oxidoreductases
KW  - Point Mutation
KW  - Polymerase Chain Reaction
KW  - Sequence Analysis, DNA
N1  - Publication Type: Case Reports; Journal Article
UR  - https://doi.org/10.1038/sj.bjc.6600208
ER  -