Maring, J G <br/><br/>
Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene.  [electronic resource] 

 -  British journal of cancer  Apr 2002 
 - 1028-33 p.  digital 
<br/><br/> Publication Type: Case Reports; Journal Article 
<br/><br/><label>ISSN: </label>0007-0920 
<br/><br/><label>Standard No.: </label>10.1038/sj.bjc.6600208  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Aged<br/>Alleles<br/>Antimetabolites, Antineoplastic--adverse effects<br/>Chromatography, High Pressure Liquid<br/>Colorectal Neoplasms--drug therapy<br/>DNA, Neoplasm--genetics<br/>Dihydrouracil Dehydrogenase (NADP)<br/>Female<br/>Fluorouracil--adverse effects<br/>Humans<br/>Leucovorin--administration & dosage<br/>Male<br/>Middle Aged<br/>Oxidoreductases--genetics<br/>Point Mutation<br/>Polymerase Chain Reaction<br/>Sequence Analysis, DNA