The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter. [electronic resource]
- The Journal of biological chemistry Jun 2002
- 22370-6 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0021-9258
10.1074/jbc.M200280200 doi
3T3 Cells Adaptor Proteins, Signal Transducing Adaptor Proteins, Vesicular Transport Animals Base Sequence Cell Line Cell Lineage Cytosine--metabolism Gene Silencing Histone Deacetylases--metabolism Histones--metabolism Humans Hydroxamic Acids--pharmacology Luciferases--metabolism Methylation Mice Models, Genetic Molecular Sequence Data Plasmids--metabolism Promoter Regions, Genetic Protein Isoforms Protein Structure, Tertiary Proteins--genetics RNA, Messenger--metabolism Reverse Transcriptase Polymerase Chain Reaction Ribonucleases--metabolism Shc Signaling Adaptor Proteins Src Homology 2 Domain-Containing, Transforming Protein 1 Time Factors Transcription, Genetic Transfection