TY  - GEN
AU  - Lin,Hsia-lien
AU  - Kent,Ute M
AU  - Hollenberg,Paul F
TI  - Mechanism-based inactivation of cytochrome P450 3A4 by 17 alpha-ethynylestradiol: evidence for heme destruction and covalent binding to protein
SN  - 0022-3565
PY  - 2002///0418
KW  - Apoproteins
KW  - metabolism
KW  - Chromatography, High Pressure Liquid
KW  - Cytochrome P-450 CYP3A
KW  - Cytochrome P-450 Enzyme Inhibitors
KW  - Cytochrome P-450 Enzyme System
KW  - chemistry
KW  - Electrophoresis, Polyacrylamide Gel
KW  - Enzyme Inhibitors
KW  - pharmacology
KW  - Escherichia coli
KW  - drug effects
KW  - Ethinyl Estradiol
KW  - Gas Chromatography-Mass Spectrometry
KW  - Heme
KW  - Mixed Function Oxygenases
KW  - antagonists & inhibitors
KW  - NADP
KW  - Oxidation-Reduction
KW  - Protein Binding
KW  - Solubility
KW  - Spectrometry, Mass, Electrospray Ionization
N1  - Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1124/jpet.301.1.160
ER  -