TY - GEN AU - Harris,Adrian L TI - Hypoxia--a key regulatory factor in tumour growth SN - 1474-175X PY - 2002///0416 KW - Animals KW - Antineoplastic Agents KW - pharmacokinetics KW - Apoptosis KW - Aryl Hydrocarbon Receptor Nuclear Translocator KW - Basic Helix-Loop-Helix Transcription Factors KW - Cell Division KW - Cell Hypoxia KW - Cell Survival KW - Cyclic AMP Response Element-Binding Protein KW - physiology KW - DNA Damage KW - DNA-Binding Proteins KW - Dimerization KW - Embryonic and Fetal Development KW - Endothelial Growth Factors KW - Erythropoietin KW - therapeutic use KW - Forecasting KW - Gene Expression Regulation KW - Glycolysis KW - Humans KW - Hydrogen-Ion Concentration KW - Hypoxia-Inducible Factor 1 KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - Lymphokines KW - Mice KW - NF-kappa B KW - Neoplasms KW - blood supply KW - Neovascularization, Pathologic KW - genetics KW - Nuclear Proteins KW - Oxidation-Reduction KW - Oxidative Stress KW - Oxygen KW - metabolism KW - Prodrugs KW - Proto-Oncogene Proteins KW - Receptor Protein-Tyrosine Kinases KW - Receptors, Aryl Hydrocarbon KW - Signal Transduction KW - Trans-Activators KW - deficiency KW - Transcription Factors KW - Vascular Endothelial Growth Factor A KW - Vascular Endothelial Growth Factor Receptor-1 KW - Vascular Endothelial Growth Factors KW - Xenograft Model Antitumor Assays N1 - Publication Type: Journal Article; Review UR - https://doi.org/10.1038/nrc704 ER -