TY  - GEN
AU  - Poulaki,Vassiliki
AU  - Qin,Wenying
AU  - Joussen,Antonia M
AU  - Hurlbut,Peter
AU  - Wiegand,Stanley J
AU  - Rudge,John
AU  - Yancopoulos,George D
AU  - Adamis,Anthony P
TI  - Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF
SN  - 0021-9738
PY  - 2002///0418
KW  - Animals
KW  - Blood-Retinal Barrier
KW  - drug effects
KW  - Cell Nucleus
KW  - metabolism
KW  - Cells, Cultured
KW  - Culture Media, Conditioned
KW  - DNA-Binding Proteins
KW  - Diabetes Mellitus
KW  - physiopathology
KW  - Diabetic Retinopathy
KW  - Disease Models, Animal
KW  - Drug Implants
KW  - Endothelial Growth Factors
KW  - genetics
KW  - Glucose
KW  - Humans
KW  - Hypoxia-Inducible Factor 1
KW  - Hypoxia-Inducible Factor 1, alpha Subunit
KW  - Insulin
KW  - pharmacology
KW  - Lymphokines
KW  - Male
KW  - Mitogen-Activated Protein Kinases
KW  - antagonists & inhibitors
KW  - Nuclear Proteins
KW  - Phosphatidylinositol 3-Kinases
KW  - Phosphoinositide-3 Kinase Inhibitors
KW  - Proto-Oncogene Proteins
KW  - Rats
KW  - Rats, Long-Evans
KW  - Receptor Protein-Tyrosine Kinases
KW  - Recombinant Fusion Proteins
KW  - Retina
KW  - cytology
KW  - Transcription Factors
KW  - Transcriptional Activation
KW  - physiology
KW  - Vascular Endothelial Growth Factor A
KW  - Vascular Endothelial Growth Factor Receptor-1
KW  - Vascular Endothelial Growth Factors
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1172/JCI13776
ER  -