Poulaki, Vassiliki <br/><br/>
Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF.  [electronic resource] 

 -  The Journal of clinical investigation  Mar 2002 
 - 805-15 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. 
<br/><br/><label>ISSN: </label>0021-9738 
<br/><br/><label>Standard No.: </label>10.1172/JCI13776  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Blood-Retinal Barrier--drug effects<br/>Cell Nucleus--metabolism<br/>Cells, Cultured<br/>Culture Media, Conditioned<br/>DNA-Binding Proteins--metabolism<br/>Diabetes Mellitus--physiopathology<br/>Diabetic Retinopathy--physiopathology<br/>Disease Models, Animal<br/>Drug Implants<br/>Endothelial Growth Factors--genetics<br/>Glucose--metabolism<br/>Humans<br/>Hypoxia-Inducible Factor 1<br/>Hypoxia-Inducible Factor 1, alpha Subunit<br/>Insulin--pharmacology<br/>Lymphokines--genetics<br/>Male<br/>Mitogen-Activated Protein Kinases--antagonists & inhibitors<br/>Nuclear Proteins--metabolism<br/>Phosphatidylinositol 3-Kinases--metabolism<br/>Phosphoinositide-3 Kinase Inhibitors<br/>Proto-Oncogene Proteins--genetics<br/>Rats<br/>Rats, Long-Evans<br/>Receptor Protein-Tyrosine Kinases--genetics<br/>Recombinant Fusion Proteins--metabolism<br/>Retina--cytology<br/>Transcription Factors--metabolism<br/>Transcriptional Activation--physiology<br/>Vascular Endothelial Growth Factor A<br/>Vascular Endothelial Growth Factor Receptor-1<br/>Vascular Endothelial Growth Factors