Liu, Dongbo

Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus. [electronic resource] - Endocrinology Apr 2002 - 1225-34 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0013-7227

10.1210/endo.143.4.8737 doi


Adenoviridae Infections--pathology
Animals
Apoptosis--physiology
Cell Death--drug effects
Cells, Cultured
Chemokines--biosynthesis
Cytokines--biosynthesis
Diabetes Mellitus, Type 1--physiopathology
Fas Ligand Protein
Insulin--biosynthesis
Interferon-gamma--pharmacology
Interleukin-1--pharmacology
Islets of Langerhans--drug effects
Luciferases--metabolism
Male
Membrane Glycoproteins--biosynthesis
NF-kappa B--physiology
Poly I-C--pharmacology
RNA, Double-Stranded--physiology
RNA, Messenger--biosynthesis
Rats
Rats, Wistar
Reverse Transcriptase Polymerase Chain Reaction
Transfection