Rituximab modifies the cisplatin-mitochondrial signaling pathway, resulting in apoptosis in cisplatin-resistant non-Hodgkin's lymphoma. [electronic resource]
- Clinical cancer research : an official journal of the American Association for Cancer Research Mar 2002
- 836-45 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
1078-0432
Antibodies, Monoclonal--pharmacology Antibodies, Monoclonal, Murine-Derived Antineoplastic Combined Chemotherapy Protocols Apoptosis--drug effects Apoptotic Protease-Activating Factor 1 Blotting, Western CASP8 and FADD-Like Apoptosis Regulating Protein Carrier Proteins Caspase Inhibitors Caspases--metabolism Cisplatin--pharmacology Combined Modality Therapy Cytochrome c Group--metabolism Dose-Response Relationship, Drug Drug Resistance, Neoplasm Enzyme Activation--drug effects Enzyme Inhibitors--pharmacology Fas Ligand Protein Humans Intracellular Signaling Peptides and Proteins Lymphoma, AIDS-Related--metabolism Membrane Glycoproteins--metabolism Mitochondria--drug effects Proteins--metabolism Proto-Oncogene Proteins c-bcl-2--metabolism Reactive Oxygen Species--metabolism Reverse Transcriptase Polymerase Chain Reaction Rituximab Signal Transduction--drug effects Tumor Cells, Cultured--drug effects fas Receptor--metabolism