TY  - GEN
AU  - Eagling,V A
AU  - Wiltshire,H
AU  - Whitcombe,I W A
AU  - Back,D J
TI  - CYP3A4-mediated hepatic metabolism of the HIV-1 protease inhibitor saquinavir in vitro
SN  - 0049-8254
PY  - 2002///0731
KW  - Adult
KW  - Biological Availability
KW  - Chromatography, High Pressure Liquid
KW  - Cytochrome P-450 CYP3A
KW  - Cytochrome P-450 Enzyme Inhibitors
KW  - Cytochrome P-450 Enzyme System
KW  - genetics
KW  - DNA, Complementary
KW  - Enzyme Inhibitors
KW  - pharmacology
KW  - Female
KW  - Gene Expression
KW  - HIV Protease Inhibitors
KW  - chemistry
KW  - Humans
KW  - In Vitro Techniques
KW  - Indinavir
KW  - Ketoconazole
KW  - Kinetics
KW  - Magnetic Resonance Spectroscopy
KW  - Male
KW  - Mass Spectrometry
KW  - Microsomes, Liver
KW  - drug effects
KW  - Mixed Function Oxygenases
KW  - antagonists & inhibitors
KW  - Nelfinavir
KW  - Ritonavir
KW  - Saquinavir
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1080/00498250110085845
ER  -