Eagling, V A <br/><br/>
CYP3A4-mediated hepatic metabolism of the HIV-1 protease inhibitor saquinavir in vitro.  [electronic resource] 

 -  Xenobiotica; the fate of foreign compounds in biological systems  Jan 2002 
 - 1-17 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0049-8254 
<br/><br/><label>Standard No.: </label>10.1080/00498250110085845  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adult<br/>Biological Availability<br/>Chromatography, High Pressure Liquid<br/>Cytochrome P-450 CYP3A<br/>Cytochrome P-450 Enzyme Inhibitors<br/>Cytochrome P-450 Enzyme System--genetics<br/>DNA, Complementary--genetics<br/>Enzyme Inhibitors--pharmacology<br/>Female<br/>Gene Expression<br/>HIV Protease Inhibitors--chemistry<br/>Humans<br/>In Vitro Techniques<br/>Indinavir--pharmacology<br/>Ketoconazole--pharmacology<br/>Kinetics<br/>Magnetic Resonance Spectroscopy<br/>Male<br/>Mass Spectrometry<br/>Microsomes, Liver--drug effects<br/>Mixed Function Oxygenases--antagonists & inhibitors<br/>Nelfinavir--pharmacology<br/>Ritonavir--pharmacology<br/>Saquinavir--chemistry