Expression of a non-functional p53 affects the sensitivity of cancer cells to gemcitabine. [electronic resource]
- International journal of cancer Feb 2002
- 439-45 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
0020-7136
10.1002/ijc.1628 doi
Adenocarcinoma--pathology Antimetabolites, Antineoplastic--pharmacology Apoptosis--drug effects Breast Neoplasms--pathology Cyclin-Dependent Kinase Inhibitor p21 Cyclins--biosynthesis DNA Damage DNA Replication--drug effects DNA, Neoplasm--drug effects Deoxycytidine--analogs & derivatives Drug Resistance, Neoplasm--genetics Female G1 Phase--drug effects Gene Expression Regulation, Neoplastic--drug effects Genes, Dominant Genes, bcl-2 Genes, p53 Humans Neoplasm Proteins--deficiency Neoplastic Stem Cells--drug effects Phenotype Proto-Oncogene Proteins c-bcl-2--biosynthesis RNA, Messenger--biosynthesis RNA, Neoplasm--biosynthesis S Phase--drug effects Tumor Cells, Cultured--drug effects Tumor Suppressor Protein p53--deficiency bcl-X Protein Gemcitabine