Nerve growth factor-induced p75-mediated death of cultured hippocampal neurons is age-dependent and transduced through ceramide generated by neutral sphingomyelinase. [electronic resource]
- The Journal of biological chemistry Mar 2002
- 9812-8 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0021-9258
10.1074/jbc.M109862200 doi
Age Factors Amides--metabolism Animals Axons--metabolism Blotting, Western Cell Death Cells, Cultured Ceramides--metabolism Dose-Response Relationship, Drug Hippocampus--cytology Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinases--metabolism Nerve Growth Factor--metabolism Neurons--metabolism Phosphorylation Pyrones--metabolism Rats Rats, Wistar Receptor, Nerve Growth Factor Receptors, Nerve Growth Factor--metabolism Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Sphingomyelin Phosphodiesterase--metabolism Time Factors