TY - GEN AU - Borthwick,Alan D AU - Crame,Andrew J AU - Ertl,Peter F AU - Exall,Anne M AU - Haley,Terry M AU - Hart,Graham J AU - Mason,Andrew M AU - Pennell,Andrew M K AU - Singh,Onkar M P AU - Weingarten,Gordon G AU - Woolven,James M TI - Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxohexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 2. Potency and chirality SN - 0022-2623 PY - 2002///0122 KW - Antiviral Agents KW - chemical synthesis KW - Binding Sites KW - Crystallography, X-Ray KW - Cytomegalovirus KW - chemistry KW - Lactams KW - Mass Spectrometry KW - Models, Molecular KW - Protease Inhibitors KW - Pyrroles KW - Serine Endopeptidases KW - Stereoisomerism KW - Structure-Activity Relationship N1 - Publication Type: Journal Article UR - https://doi.org/10.1021/jm0102203 ER -