TY  - GEN
AU  - Uckun,Fatih M
AU  - Thoen,Jason
AU  - Chen,Hao
AU  - Sudbeck,Elise
AU  - Mao,Chen
AU  - Malaviya,Ravi
AU  - Liu,Xing-Ping
AU  - Chen,Chun-Lin
TI  - CYP1A-mediated metabolism of the Janus kinase-3 inhibitor 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline: structural basis for inactivation by regioselective O-demethylation
SN  - 0090-9556
PY  - 2002///0206
KW  - Animals
KW  - Capillary Permeability
KW  - drug effects
KW  - Cell Line
KW  - Chromatography, High Pressure Liquid
KW  - Cytochrome P-450 CYP1A1
KW  - metabolism
KW  - Cytochrome P-450 CYP1A2
KW  - Dogs
KW  - Enzyme Inhibitors
KW  - Female
KW  - Guinea Pigs
KW  - Humans
KW  - In Vitro Techniques
KW  - Janus Kinase 3
KW  - Macaca fascicularis
KW  - Mast Cells
KW  - Mice
KW  - Microsomes, Liver
KW  - enzymology
KW  - Models, Molecular
KW  - Passive Cutaneous Anaphylaxis
KW  - Protein Binding
KW  - Protein-Tyrosine Kinases
KW  - antagonists & inhibitors
KW  - Quinazolines
KW  - Rabbits
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Recombinant Proteins
KW  - Species Specificity
KW  - Stereoisomerism
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1124/dmd.30.1.74
ER  -