Uckun, Fatih M <br/><br/>
CYP1A-mediated metabolism of the Janus kinase-3 inhibitor 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline: structural basis for inactivation by regioselective O-demethylation.  [electronic resource] 

 -  Drug metabolism and disposition: the biological fate of chemicals  Jan 2002 
 - 74-85 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0090-9556 
<br/><br/><label>Standard No.: </label>10.1124/dmd.30.1.74  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Capillary Permeability--drug effects<br/>Cell Line<br/>Chromatography, High Pressure Liquid<br/>Cytochrome P-450 CYP1A1--metabolism<br/>Cytochrome P-450 CYP1A2--metabolism<br/>Dogs<br/>Enzyme Inhibitors--metabolism<br/>Female<br/>Guinea Pigs<br/>Humans<br/>In Vitro Techniques<br/>Janus Kinase 3<br/>Macaca fascicularis<br/>Mast Cells--metabolism<br/>Mice<br/>Microsomes, Liver--enzymology<br/>Models, Molecular<br/>Passive Cutaneous Anaphylaxis--drug effects<br/>Protein Binding<br/>Protein-Tyrosine Kinases--antagonists & inhibitors<br/>Quinazolines--metabolism<br/>Rabbits<br/>Rats<br/>Rats, Sprague-Dawley<br/>Recombinant Proteins--metabolism<br/>Species Specificity<br/>Stereoisomerism