TY - GEN AU - Foda,H D AU - Rollo,E E AU - Drews,M AU - Conner,C AU - Appelt,K AU - Shalinsky,D R AU - Zucker,S TI - Ventilator-induced lung injury upregulates and activates gelatinases and EMMPRIN: attenuation by the synthetic matrix metalloproteinase inhibitor, Prinomastat (AG3340) SN - 1044-1549 PY - 2002///0204 KW - ADAM Proteins KW - ADAM17 Protein KW - Acute Disease KW - Animals KW - Antigens, CD KW - Antigens, Neoplasm KW - Antineoplastic Agents KW - administration & dosage KW - Barotrauma KW - drug therapy KW - Basigin KW - Capillary Permeability KW - Culture Media, Conditioned KW - Drug Evaluation, Preclinical KW - Enzyme Induction KW - Enzyme Inhibitors KW - Fibroblasts KW - drug effects KW - Injections, Intraperitoneal KW - Lung KW - enzymology KW - Lung Injury KW - Matrix Metalloproteinase 2 KW - metabolism KW - Matrix Metalloproteinase 9 KW - Matrix Metalloproteinase Inhibitors KW - Membrane Glycoproteins KW - antagonists & inhibitors KW - Metalloendopeptidases KW - Models, Animal KW - Organic Chemicals KW - Positive-Pressure Respiration KW - adverse effects KW - Premedication KW - Pressure KW - Rats KW - Rats, Sprague-Dawley KW - Respiratory Distress Syndrome KW - etiology KW - Stress, Mechanical KW - Tumor Necrosis Factor-alpha KW - biosynthesis KW - Ventilators, Mechanical N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S UR - https://doi.org/10.1165/ajrcmb.25.6.4558f ER -