TY  - GEN
AU  - Talon,S
AU  - De Luca,A
AU  - De Bellis,M
AU  - Desaphy,J F
AU  - Lentini,G
AU  - Scilimati,A
AU  - Corbo,F
AU  - Franchini,C
AU  - Tortorella,P
AU  - Jockusch,H
AU  - Conte Camerino,D
TI  - Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo
SN  - 0007-1188
PY  - 2002///0114
KW  - Animals
KW  - Anti-Arrhythmia Agents
KW  - pharmacology
KW  - Dose-Response Relationship, Drug
KW  - In Vitro Techniques
KW  - Membrane Potentials
KW  - drug effects
KW  - Mice
KW  - Mice, Mutant Strains
KW  - Muscle Contraction
KW  - Muscle, Skeletal
KW  - Mutation
KW  - Myotonia
KW  - drug therapy
KW  - Rana esculenta
KW  - Sodium Channel Blockers
KW  - Sodium Channels
KW  - physiology
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
KW  - Tocainide
KW  - chemistry
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/sj.bjp.0704366
ER  -