Talon, S <br/><br/>
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo.  [electronic resource] 

 -  British journal of pharmacology  Dec 2001 
 - 1523-31 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0007-1188 
<br/><br/><label>Standard No.: </label>10.1038/sj.bjp.0704366  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Anti-Arrhythmia Agents--pharmacology<br/>Dose-Response Relationship, Drug<br/>In Vitro Techniques<br/>Membrane Potentials--drug effects<br/>Mice<br/>Mice, Mutant Strains<br/>Muscle Contraction--drug effects<br/>Muscle, Skeletal--drug effects<br/>Mutation<br/>Myotonia--drug therapy<br/>Rana esculenta<br/>Sodium Channel Blockers<br/>Sodium Channels--physiology<br/>Stereoisomerism<br/>Structure-Activity Relationship<br/>Tocainide--chemistry