TY - GEN AU - Lee,S B AU - Kim,S H AU - Bell,D W AU - Wahrer,D C AU - Schiripo,T A AU - Jorczak,M M AU - Sgroi,D C AU - Garber,J E AU - Li,F P AU - Nichols,K E AU - Varley,J M AU - Godwin,A K AU - Shannon,K M AU - Harlow,E AU - Haber,D A TI - Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome SN - 0008-5472 PY - 2001///1212 KW - Adult KW - Base Sequence KW - Checkpoint Kinase 2 KW - Colonic Neoplasms KW - genetics KW - DNA, Complementary KW - Female KW - Gene Expression Regulation, Neoplastic KW - Gene Silencing KW - Genes, p53 KW - Humans KW - Li-Fraumeni Syndrome KW - enzymology KW - Loss of Heterozygosity KW - Male KW - Molecular Sequence Data KW - Mutation, Missense KW - Pedigree KW - Protein Kinases KW - Protein Serine-Threonine Kinases KW - Tumor Cells, Cultured N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S ER -