Regulation of type-II collagen gene expression during human chondrocyte de-differentiation and recovery of chondrocyte-specific phenotype in culture involves Sry-type high-mobility-group box (SOX) transcription factors. [electronic resource]
- The Biochemical journal Dec 2001
- 461-70 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0264-6021
10.1042/0264-6021:3600461 doi
Animals Base Sequence Cattle Cell Culture Techniques--methods Cell Differentiation--genetics Cells, Cultured Chondrocytes--cytology Collagen Type II--biosynthesis DNA-Binding Proteins--metabolism Enhancer Elements, Genetic Fetus Gene Expression Profiling Gene Expression Regulation, Developmental High Mobility Group Proteins--metabolism Humans Molecular Sequence Data Nuclear Proteins--metabolism Phenotype Promoter Regions, Genetic Protein Binding--genetics SOX9 Transcription Factor SOXD Transcription Factors Sex Determination Processes Sex-Determining Region Y Protein Transcription Factors--metabolism Up-Regulation--genetics Y Chromosome--genetics