TY  - GEN
AU  - Hegmans,A
AU  - Qu,Y
AU  - Kelland,L R
AU  - Roberts,J D
AU  - Farrell,N
TI  - Novel approaches to polynuclear platinum pro-drugs. Selective release of cytotoxic platinum-spermidine species through hydrolytic cleavage of carbamates
SN  - 0020-1669
PY  - 2002///0130
KW  - Animals
KW  - Antineoplastic Agents
KW  - chemical synthesis
KW  - Carbamates
KW  - chemistry
KW  - Catalysis
KW  - Chromatography, High Pressure Liquid
KW  - Female
KW  - Humans
KW  - Hydrogen-Ion Concentration
KW  - Hydrolysis
KW  - Inhibitory Concentration 50
KW  - Leukemia L1210
KW  - Mice
KW  - Molecular Structure
KW  - Nuclear Magnetic Resonance, Biomolecular
KW  - Organoplatinum Compounds
KW  - Ovarian Neoplasms
KW  - Polyamines
KW  - Prodrugs
KW  - Spermidine
KW  - Spermine
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
KW  - Temperature
KW  - Tumor Cells, Cultured
KW  - drug effects
N1  - Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1021/ic010509a
ER  -