Hegmans, A <br/><br/>
Novel approaches to polynuclear platinum pro-drugs. Selective release of cytotoxic platinum-spermidine species through hydrolytic cleavage of carbamates.  [electronic resource] 

 -  Inorganic chemistry  Nov 2001 
 - 6108-14 p.  digital 
<br/><br/> Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. 
<br/><br/><label>ISSN: </label>0020-1669 
<br/><br/><label>Standard No.: </label>10.1021/ic010509a  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antineoplastic Agents--chemical synthesis<br/>Carbamates--chemistry<br/>Catalysis<br/>Chromatography, High Pressure Liquid<br/>Female<br/>Humans<br/>Hydrogen-Ion Concentration<br/>Hydrolysis<br/>Inhibitory Concentration 50<br/>Leukemia L1210<br/>Mice<br/>Molecular Structure<br/>Nuclear Magnetic Resonance, Biomolecular<br/>Organoplatinum Compounds--chemical synthesis<br/>Ovarian Neoplasms<br/>Polyamines--chemical synthesis<br/>Prodrugs--chemical synthesis<br/>Spermidine--chemistry<br/>Spermine--chemistry<br/>Stereoisomerism<br/>Structure-Activity Relationship<br/>Temperature<br/>Tumor Cells, Cultured--drug effects