TY  - GEN
AU  - Freson,K
AU  - Hoylaerts,M F
AU  - Jaeken,J
AU  - Eyssen,M
AU  - Arnout,J
AU  - Vermylen,J
AU  - Van Geet,C
TI  - Genetic variation of the extra-large stimulatory G protein alpha-subunit leads to Gs hyperfunction in platelets and is a risk factor for bleeding
SN  - 0340-6245
PY  - 2002///0408
KW  - Abnormalities, Multiple
KW  - genetics
KW  - Adenosine
KW  - pharmacology
KW  - Adenylyl Cyclases
KW  - metabolism
KW  - Adolescent
KW  - Alprostadil
KW  - Alternative Splicing
KW  - Amino Acid Sequence
KW  - Amino Acid Substitution
KW  - Bleeding Time
KW  - Blood Platelets
KW  - physiology
KW  - Child
KW  - Chromogranins
KW  - Cyclic AMP
KW  - biosynthesis
KW  - Female
KW  - Fingers
KW  - abnormalities
KW  - GTP-Binding Protein alpha Subunits, Gs
KW  - Gene Frequency
KW  - Genomic Imprinting
KW  - Hemorrhagic Disorders
KW  - epidemiology
KW  - Heterotrimeric GTP-Binding Proteins
KW  - Humans
KW  - Hyperkinesis
KW  - Hypoparathyroidism
KW  - Iloprost
KW  - Intellectual Disability
KW  - Male
KW  - Molecular Sequence Data
KW  - Muscle Hypotonia
KW  - Mutagenesis, Insertional
KW  - Nerve Tissue Proteins
KW  - Phenotype
KW  - Platelet Aggregation
KW  - drug effects
KW  - Platelet Function Tests
KW  - Polymorphism, Genetic
KW  - Protein Subunits
KW  - Repetitive Sequences, Amino Acid
KW  - Risk Factors
KW  - Second Messenger Systems
KW  - Structure-Activity Relationship
KW  - Wounds and Injuries
KW  - complications
N1  - Publication Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't
ER  -