Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability. [electronic resource]
- The Journal of biological chemistry Nov 2001
- 43175-81 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0021-9258
10.1074/jbc.M105895200 doi
3T3 Cells Adenocarcinoma--genetics Alleles Amino Acids--chemistry Animals Blotting, Western Cell Line Codon Codon, Nonsense Cycloheximide--pharmacology DNA-Binding Proteins--chemistry Genes, Dominant Humans Loss of Heterozygosity Mesoderm--metabolism Mice Models, Molecular Mutation Nerve Growth Factors Pancreatic Neoplasms--chemistry Plasmids--metabolism Precipitin Tests Protein Binding Protein Structure, Tertiary Protein Synthesis Inhibitors--pharmacology RNA, Messenger--metabolism Ribonucleases--metabolism Signal Transduction Smad Proteins Smad2 Protein Smad4 Protein Time Factors Trans-Activators--chemistry Transcription, Genetic Transforming Growth Factor beta--metabolism Ubiquitin--pharmacology Xenopus Xenopus Proteins