TY  - GEN
AU  - Bell,I M
AU  - Gallicchio,S N
AU  - Abrams,M
AU  - Beshore,D C
AU  - Buser,C A
AU  - Culberson,J C
AU  - Davide,J
AU  - Ellis-Hutchings,M
AU  - Fernandes,C
AU  - Gibbs,J B
AU  - Graham,S L
AU  - Hartman,G D
AU  - Heimbrook,D C
AU  - Homnick,C F
AU  - Huff,J R
AU  - Kassahun,K
AU  - Koblan,K S
AU  - Kohl,N E
AU  - Lobell,R B
AU  - Lynch,J J
AU  - Miller,P A
AU  - Omer,C A
AU  - Rodrigues,A D
AU  - Walsh,E S
AU  - Williams,T M
TI  - Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency
SN  - 0022-2623
PY  - 2001///0927
KW  - Alkyl and Aryl Transferases
KW  - antagonists & inhibitors
KW  - Animals
KW  - Antineoplastic Agents
KW  - chemical synthesis
KW  - Binding Sites
KW  - Binding, Competitive
KW  - Biological Availability
KW  - Cell Line, Transformed
KW  - Dogs
KW  - Drug Design
KW  - Drug Screening Assays, Antitumor
KW  - Enzyme Inhibitors
KW  - Farnesyltranstransferase
KW  - Genes, ras
KW  - Imidazoles
KW  - Lactams
KW  - Mice
KW  - Mice, Transgenic
KW  - Models, Molecular
KW  - Neoplasms, Experimental
KW  - pathology
KW  - Nitriles
KW  - Pyrrolidinones
KW  - Radioligand Assay
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm010156p
ER  -