TY  - GEN
AU  - Thomas,J B
AU  - Atkinson,R N
AU  - Rothman,R B
AU  - Fix,S E
AU  - Mascarella,S W
AU  - Vinson,N A
AU  - Xu,H
AU  - Dersch,C M
AU  - Lu,Y
AU  - Cantrell,B E
AU  - Zimmerman,D M
AU  - Carroll,F I
TI  - Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity
SN  - 0022-2623
PY  - 2001///0906
KW  - Animals
KW  - Binding, Competitive
KW  - Brain
KW  - metabolism
KW  - Cloning, Molecular
KW  - Guinea Pigs
KW  - Humans
KW  - In Vitro Techniques
KW  - Isoquinolines
KW  - chemical synthesis
KW  - Narcotic Antagonists
KW  - Piperidines
KW  - Radioligand Assay
KW  - Rats
KW  - Receptors, Opioid, delta
KW  - antagonists & inhibitors
KW  - Receptors, Opioid, kappa
KW  - Receptors, Opioid, mu
KW  - Structure-Activity Relationship
KW  - Tetrahydroisoquinolines
N1  - Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1021/jm015521r
ER  -