Thomas, J B <br/><br/>
Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity.  [electronic resource] 

 -  Journal of medicinal chemistry  Aug 2001 
 - 2687-90 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S. 
<br/><br/><label>ISSN: </label>0022-2623 
<br/><br/><label>Standard No.: </label>10.1021/jm015521r  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Binding, Competitive<br/>Brain--metabolism<br/>Cloning, Molecular<br/>Guinea Pigs<br/>Humans<br/>In Vitro Techniques<br/>Isoquinolines--chemical synthesis<br/>Narcotic Antagonists--chemical synthesis<br/>Piperidines--chemical synthesis<br/>Radioligand Assay<br/>Rats<br/>Receptors, Opioid, delta--antagonists & inhibitors<br/>Receptors, Opioid, kappa--antagonists & inhibitors<br/>Receptors, Opioid, mu--antagonists & inhibitors<br/>Structure-Activity Relationship<br/>Tetrahydroisoquinolines