TY - GEN AU - Yan,R AU - Han,P AU - Miao,H AU - Greengard,P AU - Xu,H TI - The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate SN - 0021-9258 PY - 2001///1101 KW - Alzheimer Disease KW - metabolism KW - Amyloid Precursor Protein Secretases KW - Amyloid beta-Protein Precursor KW - chemistry KW - Animals KW - Aspartic Acid Endopeptidases KW - Biotinylation KW - Catalytic Domain KW - Cell Line KW - Cell Membrane KW - Endopeptidases KW - Endoplasmic Reticulum KW - Golgi Apparatus KW - Green Fluorescent Proteins KW - Humans KW - Luminescent Proteins KW - Mice KW - Microscopy, Fluorescence KW - Models, Genetic KW - Plasmids KW - Protein Structure, Tertiary KW - Recombinant Fusion Proteins KW - Substrate Specificity KW - Sucrose N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S UR - https://doi.org/10.1074/jbc.M104350200 ER -