Meng, L <br/><br/>
Induction of bulk and c-myc P2 promoter-specific DNA damage by an anti-topoisomerase II agent salvicine is an early event leading to apoptosis in HL-60 cells.  [electronic resource] 

 -  FEBS letters  Jul 2001 
 - 59-64 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0014-5793 
<br/><br/><label>Standard No.: </label>10.1016/s0014-5793(01)02633-3  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antineoplastic Agents, Phytogenic--pharmacology<br/>Apoptosis--drug effects<br/>Cell Division--drug effects<br/>DNA Damage--drug effects<br/>DNA Fragmentation--drug effects<br/>DNA Topoisomerases, Type II--metabolism<br/>Dose-Response Relationship, Drug<br/>Enzyme Inhibitors--pharmacology<br/>Gene Expression Regulation--drug effects<br/>Genes, fos--genetics<br/>Genes, jun--genetics<br/>Genes, myc--genetics<br/>HL-60 Cells<br/>Humans<br/>Naphthoquinones--chemistry<br/>Promoter Regions, Genetic--genetics<br/>RNA Stability--drug effects<br/>RNA, Messenger--genetics<br/>Substrate Specificity<br/>Topoisomerase II Inhibitors