TY  - GEN
AU  - Berezovska,O
AU  - Jack,C
AU  - Deng,A
AU  - Gastineau,N
AU  - Rebeck,G W
AU  - Hyman,B T
TI  - Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage
SN  - 0021-9258
PY  - 2001///0906
KW  - Amyloid Precursor Protein Secretases
KW  - Amyloid beta-Protein Precursor
KW  - metabolism
KW  - Animals
KW  - Aspartic Acid Endopeptidases
KW  - Binding, Competitive
KW  - Biotinylation
KW  - Blotting, Western
KW  - Cell Nucleus
KW  - Culture Media, Conditioned
KW  - pharmacology
KW  - Dose-Response Relationship, Drug
KW  - Endopeptidases
KW  - Enzyme Activation
KW  - Enzyme-Linked Immunosorbent Assay
KW  - Humans
KW  - Immunoblotting
KW  - Ligands
KW  - Luciferases
KW  - Membrane Proteins
KW  - Mice
KW  - Mice, Transgenic
KW  - Models, Biological
KW  - Neurons
KW  - Presenilin-1
KW  - Protein Binding
KW  - Protein Structure, Tertiary
KW  - Receptor, Notch1
KW  - Receptors, Cell Surface
KW  - Time Factors
KW  - Transcription Factors
KW  - Transfection
N1  - Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1074/jbc.M008268200
ER  -