TY  - GEN
AU  - Butrous,G
AU  - Siegel,R L
TI  - Sildenafil (Viagra) prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current
SN  - 1524-4539
PY  - 2001///0719
KW  - 3',5'-Cyclic-GMP Phosphodiesterases
KW  - antagonists & inhibitors
KW  - Administration, Oral
KW  - Animals
KW  - Biological Availability
KW  - Cation Transport Proteins
KW  - Cells, Cultured
KW  - Cricetinae
KW  - Cyclic Nucleotide Phosphodiesterases, Type 5
KW  - Cytochrome P-450 CYP3A
KW  - Cytochrome P-450 Enzyme Inhibitors
KW  - Cytochrome P-450 Enzyme System
KW  - metabolism
KW  - DNA-Binding Proteins
KW  - Dogs
KW  - Dose-Response Relationship, Drug
KW  - ERG1 Potassium Channel
KW  - Electrocardiography
KW  - drug effects
KW  - Erectile Dysfunction
KW  - drug therapy
KW  - Erythromycin
KW  - pharmacology
KW  - Ether-A-Go-Go Potassium Channels
KW  - Guinea Pigs
KW  - Heart
KW  - Heart Conduction System
KW  - Humans
KW  - Male
KW  - Mixed Function Oxygenases
KW  - Myocardium
KW  - Piperazines
KW  - administration & dosage
KW  - Potassium Channel Blockers
KW  - Potassium Channels
KW  - Potassium Channels, Voltage-Gated
KW  - Purines
KW  - Sildenafil Citrate
KW  - Sulfones
KW  - Trans-Activators
KW  - Transcriptional Regulator ERG
N1  - Publication Type: Letter; Comment
UR  - https://doi.org/10.1161/01.cir.103.23.e119
ER  -