Butrous, G <br/><br/>
Sildenafil (Viagra) prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current.  [electronic resource] 

 -  Circulation  Jun 2001 
 - E119-20; author reply E119-20 p.  digital 
<br/><br/> Publication Type: Letter; Comment 
<br/><br/><label>ISSN: </label>1524-4539 
<br/><br/><label>Standard No.: </label>10.1161/01.cir.103.23.e119  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>3',5'-Cyclic-GMP Phosphodiesterases--antagonists & inhibitors<br/>Administration, Oral<br/>Animals<br/>Biological Availability<br/>Cation Transport Proteins<br/>Cells, Cultured<br/>Cricetinae<br/>Cyclic Nucleotide Phosphodiesterases, Type 5<br/>Cytochrome P-450 CYP3A<br/>Cytochrome P-450 Enzyme Inhibitors<br/>Cytochrome P-450 Enzyme System--metabolism<br/>DNA-Binding Proteins<br/>Dogs<br/>Dose-Response Relationship, Drug<br/>ERG1 Potassium Channel<br/>Electrocardiography--drug effects<br/>Erectile Dysfunction--drug therapy<br/>Erythromycin--pharmacology<br/>Ether-A-Go-Go Potassium Channels<br/>Guinea Pigs<br/>Heart--drug effects<br/>Heart Conduction System--drug effects<br/>Humans<br/>Male<br/>Mixed Function Oxygenases--antagonists & inhibitors<br/>Myocardium--metabolism<br/>Piperazines--administration & dosage<br/>Potassium Channel Blockers<br/>Potassium Channels--metabolism<br/>Potassium Channels, Voltage-Gated<br/>Purines<br/>Sildenafil Citrate<br/>Sulfones<br/>Trans-Activators<br/>Transcriptional Regulator ERG