Moriyama, T

3-hydroxy-3-methylglutaryl coenzyme A reductase is sterol-dependently cleaved by cathepsin L-type cysteine protease in the isolated endoplasmic reticulum. [electronic resource] - Archives of biochemistry and biophysics Feb 2001 - 205-12 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0003-9861

10.1006/abbi.2000.2209 doi


Acetylcysteine--analogs & derivatives
Animals
Cathepsin L
Cathepsins--antagonists & inhibitors
Cell Extracts
Cell Line
Cell Membrane Permeability
Cricetinae
Cysteine Endopeptidases--isolation & purification
Endopeptidases
Endoplasmic Reticulum--enzymology
Epoxy Compounds--pharmacology
Hydrogen-Ion Concentration
Hydroxymethylglutaryl CoA Reductases--metabolism
Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent
Intracellular Membranes--drug effects
Leucine--analogs & derivatives
Lysosomes--enzymology
Multienzyme Complexes--antagonists & inhibitors
Protease Inhibitors--pharmacology
Proteasome Endopeptidase Complex
Protein Processing, Post-Translational--drug effects
Pyridines--pharmacology
Sonication
Sterols--pharmacology