Tissue inhibitor of metalloproteinase-1 prevents cytokine-mediated dysfunction and cytotoxicity in pancreatic islets and beta-cells. [electronic resource]
- Diabetes May 2001
- 1047-55 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0012-1797
10.2337/diabetes.50.5.1047 doi
Animals Apoptosis--drug effects Cell Survival--drug effects Cells, Cultured Cytokines--antagonists & inhibitors DNA Fragmentation--drug effects Flow Cytometry Gene Expression Regulation, Enzymologic--drug effects Genes, Reporter Glucose--pharmacology In Vitro Techniques Insulin--metabolism Insulin Secretion Interferon-gamma--toxicity Interleukin-1--toxicity Islets of Langerhans--cytology Luciferases--genetics Mice NF-kappa B--genetics Nitric Oxide Synthase--genetics Nitric Oxide Synthase Type II Rats Recombinant Proteins--metabolism Tissue Inhibitor of Metalloproteinase-1--genetics Tissue Inhibitor of Metalloproteinase-2--pharmacology Transfection Tumor Necrosis Factor-alpha--pharmacology