Vagnoni, L M <br/><br/>
6-Acylamino-2-1[(ethylsulfonyl)oxy]-1H-isoindole-1,3-diones mechanism-based inhibitors of human leukocyte elastase and cathepsin G: effect of chirality in the 6-acylamino substituent on inhibitory potency and selectivity.  [electronic resource] 

 -  Bioorganic & medicinal chemistry  Mar 2001 
 - 637-45 p.  digital 
<br/><br/> Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0968-0896 
<br/><br/><label>Standard No.: </label>10.1016/s0968-0896(00)00281-9  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Cathepsin G<br/>Cathepsins--antagonists & inhibitors<br/>Cattle<br/>Chymotrypsin--antagonists & inhibitors<br/>Drug Stability<br/>Enzyme Inhibitors--chemical synthesis<br/>Humans<br/>Indoles--chemical synthesis<br/>Kinetics<br/>Leukocyte Elastase--antagonists & inhibitors<br/>Models, Molecular<br/>Pancreatic Elastase--antagonists & inhibitors<br/>Serine Endopeptidases<br/>Stereoisomerism<br/>Structure-Activity Relationship<br/>Substrate Specificity<br/>Swine<br/>Thermodynamics