Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation. [electronic resource]
- Proceedings of the National Academy of Sciences of the United States of America Apr 2001
- 5025-30 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0027-8424
10.1073/pnas.091100298 doi
Animals Animals, Newborn Calcium--pharmacology Carcinoma, Squamous Cell--genetics Cell Cycle Cell Differentiation--drug effects Cell Size--drug effects Cell Transformation, Neoplastic Cells, Cultured Cyclin-Dependent Kinase Inhibitor p16--metabolism DNA--biosynthesis Gene Deletion Keratinocytes--cytology Mice Mice, Nude Neoplasm Transplantation Nuclear Matrix--metabolism Nuclear Proteins Oncogene Protein p21(ras)--metabolism Protein Transport Proteins--genetics Proto-Oncogene Proteins--metabolism Proto-Oncogene Proteins c-mdm2 Signal Transduction Tumor Suppressor Protein p14ARF Tumor Suppressor Protein p53--deficiency