Chiosis, G <br/><br/>
A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells.  [electronic resource] 

 -  Chemistry & biology  Mar 2001 
 - 289-99 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1074-5521 
<br/><br/><label>Standard No.: </label>10.1016/s1074-5521(01)00015-1  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adenine Nucleotides--metabolism<br/>Benzoquinones<br/>Binding, Competitive<br/>Breast Neoplasms--pathology<br/>Cell Cycle--drug effects<br/>Cell Differentiation--drug effects<br/>Drug Design<br/>Female<br/>HSP90 Heat-Shock Proteins--metabolism<br/>Humans<br/>Lactams, Macrocyclic<br/>Protein Binding<br/>Quinones--metabolism<br/>Receptor, ErbB-2--drug effects<br/>Tumor Cells, Cultured--drug effects