TY  - GEN
AU  - Sapkota,G P
AU  - Kieloch,A
AU  - Lizcano,J M
AU  - Lain,S
AU  - Arthur,J S
AU  - Williams,M R
AU  - Morrice,N
AU  - Deak,M
AU  - Alessi,D R
TI  - Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth
SN  - 0021-9258
PY  - 2001///0726
KW  - AMP-Activated Protein Kinase Kinases
KW  - AMP-Activated Protein Kinases
KW  - Animals
KW  - Binding Sites
KW  - Calcium-Calmodulin-Dependent Protein Kinases
KW  - metabolism
KW  - Cell Division
KW  - Cell Line
KW  - Cloning, Molecular
KW  - Colforsin
KW  - pharmacology
KW  - Cyclic AMP
KW  - Cyclic AMP-Dependent Protein Kinases
KW  - Cysteine
KW  - chemistry
KW  - Enzyme Activation
KW  - Enzyme Inhibitors
KW  - Epidermal Growth Factor
KW  - Glutathione Transferase
KW  - Humans
KW  - Immunoblotting
KW  - Isoquinolines
KW  - Mevalonic Acid
KW  - Mice
KW  - Models, Biological
KW  - Mutation
KW  - Peutz-Jeghers Syndrome
KW  - genetics
KW  - Phosphorylation
KW  - Precipitin Tests
KW  - Protein Prenylation
KW  - Protein Serine-Threonine Kinases
KW  - Rats
KW  - Ribosomal Protein S6 Kinases
KW  - Ribosomal Protein S6 Kinases, 90-kDa
KW  - Serine
KW  - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
KW  - Sulfonamides
KW  - Time Factors
KW  - Transfection
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1074/jbc.M009953200
ER  -