TY  - GEN
AU  - Clancy,D J
AU  - Gems,D
AU  - Harshman,L G
AU  - Oldham,S
AU  - Stocker,H
AU  - Hafen,E
AU  - Leevers,S J
AU  - Partridge,L
TI  - Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
SN  - 0036-8075
PY  - 2001///0607
KW  - Aging
KW  - physiology
KW  - Alleles
KW  - Animals
KW  - Body Constitution
KW  - Carrier Proteins
KW  - genetics
KW  - Crosses, Genetic
KW  - Drosophila Proteins
KW  - Drosophila melanogaster
KW  - Female
KW  - Fertility
KW  - Genes, Insect
KW  - Heterozygote
KW  - Hot Temperature
KW  - Insect Proteins
KW  - Insulin
KW  - metabolism
KW  - Insulin Receptor Substrate Proteins
KW  - Intracellular Signaling Peptides and Proteins
KW  - Longevity
KW  - Male
KW  - Mutation
KW  - Oxidative Stress
KW  - Protein-Tyrosine Kinases
KW  - Receptor Protein-Tyrosine Kinases
KW  - Receptor, Insulin
KW  - Reproduction
KW  - Signal Transduction
KW  - Somatomedins
KW  - Starvation
KW  - Superoxide Dismutase
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1126/science.1057991
ER  -