Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection: increased expression of p21(WAF1/Cip1) as a disease marker and the influence of immunosuppressive drugs. [electronic resource]
- The American journal of pathology Apr 2001
- 1379-90 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
0002-9440
10.1016/S0002-9440(10)64089-8 doi
Animals Antibodies--pharmacology Bile Ducts--pathology Biomarkers Cell Division--drug effects Cellular Senescence--physiology Chronic Disease Cyclin-Dependent Kinase Inhibitor p21 Cyclins--metabolism Cyclosporine--pharmacology Epithelial Cells--pathology Graft Rejection--drug therapy Humans Immunosuppressive Agents--therapeutic use Intracellular Membranes--metabolism Liver Transplantation Male Mice RNA, Messenger--metabolism Signal Transduction--physiology Tacrolimus--pharmacology Time Factors Transforming Growth Factor beta--genetics