Micrococci and peptidoglycan activate TLR2-->MyD88-->IRAK-->TRAF-->NIK-->IKK-->NF-kappaB signal transduction pathway that induces transcription of interleukin-8. [electronic resource]
- Infection and immunity Apr 2001
- 2270-6 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0019-9567
10.1128/IAI.69.4.2270-2276.2001 doi
Adaptor Proteins, Signal Transducing Antigens, Differentiation--physiology Cell Line Drosophila Proteins Humans I-kappa B Kinase Interleukin-1 Receptor-Associated Kinases Interleukin-8--genetics Membrane Glycoproteins--physiology Micrococcus--physiology Myeloid Differentiation Factor 88 NF-kappa B--physiology Peptidoglycan--pharmacology Protein Kinases--physiology Protein Serine-Threonine Kinases--physiology Proteins--physiology Receptors, Cell Surface--physiology Receptors, Immunologic Signal Transduction TNF Receptor-Associated Factor 6 Toll-Like Receptor 1 Toll-Like Receptor 2 Toll-Like Receptor 4 Toll-Like Receptors Transcriptional Activation NF-kappaB-Inducing Kinase