TY  - GEN
AU  - Xie,W
AU  - Radominska-Pandya,A
AU  - Shi,Y
AU  - Simon,C M
AU  - Nelson,M C
AU  - Ong,E S
AU  - Waxman,D J
AU  - Evans,R M
TI  - An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids
SN  - 0027-8424
PY  - 2001///1204
KW  - Animals
KW  - Aryl Hydrocarbon Hydroxylases
KW  - Bile Acids and Salts
KW  - metabolism
KW  - Cell Line
KW  - Cell Nucleus
KW  - Chlorocebus aethiops
KW  - Cholestasis
KW  - Cytochrome P-450 CYP3A
KW  - Cytochrome P-450 Enzyme System
KW  - Enzyme Induction
KW  - Humans
KW  - Lithocholic Acid
KW  - administration & dosage
KW  - Mice
KW  - Mice, Knockout
KW  - Oxidoreductases, N-Demethylating
KW  - Pregnane X Receptor
KW  - Rats
KW  - Receptors, Cytoplasmic and Nuclear
KW  - physiology
KW  - Receptors, Steroid
KW  - Substrate Specificity
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1073/pnas.051014398
ER  -