An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. [electronic resource]
- Proceedings of the National Academy of Sciences of the United States of America Mar 2001
- 3375-80 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0027-8424
10.1073/pnas.051014398 doi
Animals Aryl Hydrocarbon Hydroxylases Bile Acids and Salts--metabolism Cell Line Cell Nucleus Chlorocebus aethiops Cholestasis--metabolism Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System--metabolism Enzyme Induction Humans Lithocholic Acid--administration & dosage Mice Mice, Knockout Oxidoreductases, N-Demethylating--metabolism Pregnane X Receptor Rats Receptors, Cytoplasmic and Nuclear--physiology Receptors, Steroid--physiology Substrate Specificity