A mutation of the Wilson disease protein, ATP7B, is degraded in the proteasomes and forms protein aggregates. [electronic resource]
- Gastroenterology Mar 2001
- 967-74 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0016-5085
10.1053/gast.2001.22543 doi
Acetylcysteine--analogs & derivatives Adenosine Triphosphatases--genetics Carrier Proteins--genetics Cation Transport Proteins Cell Line Copper-Transporting ATPases Cysteine Endopeptidases--drug effects Cytoskeleton--ultrastructure Fluorescent Antibody Technique Humans Leupeptins--pharmacology Microscopy, Confocal Microscopy, Electron Multienzyme Complexes--drug effects Mutation--physiology Proteasome Endopeptidase Complex Tissue Distribution