TY - GEN AU - Mans,D R AU - Di Leone,L AU - Ferrary Caldas,A P AU - Maino,M AU - Almeida,L AU - Cancela,A I AU - Grivicich,I AU - Brondani da Rocha,A AU - Schwartsmann,G TI - Cellular and clinical pharmacokinetic/pharmacodynamic basis for lack of efficacy of 21-day continuous topotecan in patients with untreated advanced adenocarcinoma of the pancreas SN - 0300-8916 PY - 2001///0329 KW - Adenocarcinoma KW - drug therapy KW - Adult KW - Aged KW - Antineoplastic Agents KW - administration & dosage KW - Apoptosis KW - drug effects KW - Female KW - Humans KW - Infusions, Intravenous KW - Male KW - Middle Aged KW - Pancreatic Neoplasms KW - Topotecan KW - Treatment Failure N1 - Publication Type: Journal Article UR - https://doi.org/10.1177/030089160008600605 ER -