Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition. [electronic resource]
- Molecular and cellular neurosciences Feb 2001
- 329-41 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1044-7431
10.1006/mcne.2000.0904 doi
Animals Anticholesteremic Agents--pharmacology Apoptosis--drug effects Carrier Proteins--metabolism Cell Division--drug effects Cell Line, Transformed Cholesterol--pharmacology Lovastatin--pharmacology Mevalonic Acid--pharmacology Neurons--cytology Polyisoprenyl Phosphates--biosynthesis Pravastatin--pharmacology Protein Prenylation--drug effects Proto-Oncogene Proteins--metabolism Proto-Oncogene Proteins c-bcl-2--metabolism Rats Sesquiterpenes Squalene--pharmacology Stem Cells--cytology bcl-2-Associated X Protein bcl-Associated Death Protein bcl-X Protein