TY - GEN AU - Beshay,E AU - Croze,F AU - Prud'homme,G J TI - The phosphodiesterase inhibitors pentoxifylline and rolipram suppress macrophage activation and nitric oxide production in vitro and in vivo SN - 1521-6616 PY - 2001///0329 KW - 8-Bromo Cyclic Adenosine Monophosphate KW - pharmacology KW - Animals KW - Autoimmune Diseases KW - drug therapy KW - Bucladesine KW - Cells, Cultured KW - drug effects KW - Colforsin KW - Cyclic AMP KW - metabolism KW - Diabetes Mellitus, Type 1 KW - Dibutyryl Cyclic GMP KW - Disease Models, Animal KW - Drug Evaluation, Preclinical KW - Enterotoxins KW - Enzyme Induction KW - Female KW - Interferon-gamma KW - Interleukin-12 KW - Lipopolysaccharides KW - Macrophage Activation KW - Macrophages, Peritoneal KW - Mice KW - Mice, Inbred NOD KW - Nitric Oxide KW - biosynthesis KW - Nitric Oxide Synthase KW - Nitrites KW - analysis KW - Pentoxifylline KW - Phosphodiesterase Inhibitors KW - RNA, Messenger KW - Recombinant Proteins KW - Reverse Transcriptase Polymerase Chain Reaction KW - Rolipram KW - Tumor Necrosis Factor-alpha N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1006/clim.2000.4964 ER -