Beshay, E <br/><br/>
The phosphodiesterase inhibitors pentoxifylline and rolipram suppress macrophage activation and nitric oxide production in vitro and in vivo.  [electronic resource] 

 -  Clinical immunology (Orlando, Fla.)  Feb 2001 
 - 272-9 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1521-6616 
<br/><br/><label>Standard No.: </label>10.1006/clim.2000.4964  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>8-Bromo Cyclic Adenosine Monophosphate--pharmacology<br/>Animals<br/>Autoimmune Diseases--drug therapy<br/>Bucladesine--pharmacology<br/>Cells, Cultured--drug effects<br/>Colforsin--pharmacology<br/>Cyclic AMP--metabolism<br/>Diabetes Mellitus, Type 1--drug therapy<br/>Dibutyryl Cyclic GMP--pharmacology<br/>Disease Models, Animal<br/>Drug Evaluation, Preclinical<br/>Enterotoxins--pharmacology<br/>Enzyme Induction--drug effects<br/>Female<br/>Interferon-gamma--pharmacology<br/>Interleukin-12--pharmacology<br/>Lipopolysaccharides--pharmacology<br/>Macrophage Activation--drug effects<br/>Macrophages, Peritoneal--drug effects<br/>Mice<br/>Mice, Inbred NOD<br/>Nitric Oxide--biosynthesis<br/>Nitric Oxide Synthase--biosynthesis<br/>Nitrites--analysis<br/>Pentoxifylline--pharmacology<br/>Phosphodiesterase Inhibitors--pharmacology<br/>RNA, Messenger--biosynthesis<br/>Recombinant Proteins--pharmacology<br/>Reverse Transcriptase Polymerase Chain Reaction<br/>Rolipram--pharmacology<br/>Tumor Necrosis Factor-alpha--pharmacology